NFE2L2 and osteoporosis: Kou et al. [190] reported that eldecanate prevented OVX-induced osteoporosis by inhibiting BMSC senescence through modulation of SIRT1/Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) signaling, suggesting that SIRT1 activation enhances the regenerative potential of BMSCs and prevents bone loss.