SIRT1, SIRT2, and SIRT3 belong to type I, SIRT4 belongs to type II, SIRT5 belongs to type III, and SIRT6 and SIRT7 belong to subtypes IVa and IVb of type IV, respectively [68,69].The Sirtuins family are NAD+-dependent deacetylases and ADP-ribosyltransferases, which play key roles in inflammation, apoptosis, cellular metabolism, stress tolerance, and aging, and have been considered potential therapeutic targets for a wide range of diseases such as cardiovascular diseases, endocrine disorders, neoplasms, and respiratory diseases [70,71,72]. The gene discussed is SIRT1; the disease is cardiovascular disorder.