ICAM1 and atherosclerosis: In an in vitro model of chronic atherosclerosis using 25-hydroxycholesterol (25-OHC)-induced human umbilical vein endothelial cells (HUVECs), treatment with dabigatran improved endothelial integrity by decreasing mRNA expression of intercellular adhesion molecule 1 (ICAM1) and vascular endothelial growth factor A (VEGFA) [106].