In 2018, for example, Kantor et al. developed an all-in-one lentiviral vector employing CRISPR-deactivated Cas9 (dCas9) and DNA-methyltransferase 3A (DNMT3A) to edit the SNCA intron 1 methylation levels in human induced pluripotent stem cell (hiPSC)-derived dopaminergic neurons from a PD patient with the SNCA triplication locus (SNCA-Tri). Here, SNCA is linked to Parkinson disease.