SNCA and Parkinson disease: Moreover, the IND-1233-ASO conjugate efficiently decreased αSyn protein in SNc, and enhanced DA and serotonin neuron neurotransmission in the projection brain areas of the mice, such as CPu [34].To extend this study, the same design was exploited by the authors to disrupt SNCA mRNA transcription, uniquely, in the monoamine neurons of rhesus macaques and mice (PD-like mouse model overexpressing human αSyn in DA neurons of SNc/VTA) [35].