Despite not explored in cancer, molecular links between KLOTHO and inhibition of ferroptosis have been associated in previous works with the regulation of the nuclear erythroid 2-related factor 2 (Nrf2) and P53/SLC7A11/GPx4 signaling pathways, being also able to inhibit other components such as ACSL4 [98,99,100]. The gene discussed is TP53; the disease is cancer.