In Asian traditional medicinal preparations, ginger rhizomes have been used for the treatment of mild forms of rheumatoid arthritis and fever, and in line with such effect, ginger phenylpropanoids (gingerols, shogaols) were found to target phospholipases A2, inhibiting IL-1beta and prostanoid secretion and disrupting arachidonate-phospholipid remodeling [181]. The gene discussed is IL1B; the disease is rheumatoid arthritis.