Citral and ginger essential oil produced improvement in resistance to insulin and plasma lipid profile; decreased levels of sugar in blood and trimethylamine-N-oxide levels; inhibited plasma levels of inflammatory cytokines like interleukin-1β, and most importantly, inhibited the formation of aortic atherosclerotic lesions in the animals used in the study, while also leading to an increase in the abundance of microbes that are beneficial and decreased the abundance of microbes that are involved in the pathogenesis of cardiovascular diseases. The gene discussed is INS; the disease is cardiovascular disorder.