SIRT3 and fatty liver disease: Along this line, one study showed that in aging (22-month-old) rats, 6-gingerol treatment (0.05 or 0.2 mg/kg, once daily oral gavage for 7 weeks) counteracted age-related hepatic steatosis, increased fat oxidation, decreased fat synthesis, and improved mitochondrial function in the liver, upregulating mitochondrial marker enzymes such as NOX, SDH, and SIRT3 [69].