As one example, Arablou et al. performed a double-blind, placebo-controlled clinical trial with 70 type 2 diabetes patients who were allocated randomly to receive a placebo or 1600 mg ginger (equaling two capsules) for 12 weeks, and the ginger-receiving group displayed both improved metabolic parameters (reduction of fasting glucose, HbA1C, insulin, HOMA, triglycerides, and total cholesterol) as well as reduction in the level of the inflammatory markers CRP and PGE2 [123]. This evidence concerns the gene INS and type 2 diabetes mellitus.