We also used the high-throughput, aptamer-based SomaScan proteomics platform to identify high preoperative (PREOP) chitinase-3-like-protein-1 (CHI3L1/YKL-40) and high postoperative day 2 (POD2) IL-6 as risk and disease markers of postoperative delirium [19]. Here, CHI3L1 is linked to delirium.