PRF1 and cancer: We analyzed the correlation of PRF1 in cancer prognosis through the TCGA database and found that the prognosis was poorer in renal papillary cell carcinoma (KIRP), low-grade glioma of the brain (LGG), and ovaral melanoma (UVM), while it was better in adrenocortical carcinoma (ACC), breast invasive carcinoma (BRCA), head and neck carcinoma (HNSC), sarcoma (SARC), skin melanoma (SKCM), and endometrioid carcinoma (UCEC) (Figure 5).