In pancreatic cancer, it has been reported that TIL interaction with tumor cells via chemokines (CCL4, CCL5, CXCL9, and CXCL10) triggers an exogenous apoptosis initiated by CD8+ effector T cells (regulation via PRF1, cell membrane perforation, enzymatic digestion via serine proteases, and exogenous apoptosis via ligand binding) [38]. The gene discussed is PRF1; the disease is neoplasm.