Additionally, the dysregulation of enzymes involved in arachidonic acid metabolism, such as cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), has been reported in endometriotic lesions, further supporting the role of arachidonic acid-derived inflammatory mediators in the pathophysiology of endometriosis [75]. This evidence concerns the gene PTGS2 and endometriosis.