CLRN3 and colorectal carcinoma: Cellular functional experiments, including CCK-8 (Figure 7c,d), transwell assays (Figure 7e,f), and colony-formation assays (Figure 7g,h), demonstrated that suppressing CLRN3 curtails proliferation, migration, and invasion of CRC cells, underscoring the notion that CLRN3’s upregulation accelerates CRC progression.