CLRN3 and colorectal carcinoma: Additionally, qRT-PCR of the expression levels of CLRN3 in CRC cell lines (LoVo, SW480, HT-29, HCT116, and Caco2) and of normal colorectal cell line (HCoEpiC) demonstrated upregulation of CLRN3 in CRC cell lines compared to HCoEpiC, among which the expression level of CLRN3 was the highest in the SW480 cell line and the lowest in the Caco2 cell line (Figure 6c).