Interestingly, many of these gene targets were associated with the control of extracellular matrix physiology, an essential component of pathological cardiac hypertrophy, namely the transforming growth factor beta (Tgfb1) and its receptor (Tgfbr1), several collagens, Smads, fibroblasts growth factors (Fgfs), fibronectin (Fn1) among others. Here, TGFBR1 is linked to cardiac hypertrophy.