To gain insights into the molecular mechanism of auraptene on HCC ferroptosis, we treated HCCLM3 and HLE cells with auraptene, and the Western blot showed that auraptene significantly decreases the expression of SLC7A11 instead of GPX4, ACSL4 and FSP1 (Figure 5A,B). Here, ACSL4 is linked to hepatocellular carcinoma.