The results clearly showed that the Nrf2 gene and protein expression were significantly lower in the control group compared to the control group, which was associated with the significantly lower expression of the Gfer gene in the SpCA group, a result that demonstrates that mechanisms associated with the reduced antioxidant and anti-inflammatory activity of the Nrf2 gene may play a causative role in the development of pre-cancerous lesions as a cumulative risk for a predisposition to the progression to CRC [141]. Here, NFE2L2 is linked to colorectal carcinoma.