The first study to report the induction of the NRF2-HO-1 axis by an organobismuth (III) compound showed that compound III activated the NRF2/HO-1 pathway in the human colon cancer cell line DLD-1, increasing HO-1 expression and leading to the death of colorectal cancer cells [157]. The gene discussed is HMOX1; the disease is malignant colon neoplasm.