NLRP3 and obesity due to melanocortin 4 receptor deficiency: A 12-week physical exercise program in pediatric patients with obesity also modulated gut microbiota (e.g., increased Roseburia, Blautia, and Dialister, a profile that resembles that of healthy children) and reduced inflammation and NLRP3 expression [38], where the NLRP3 inflammasome activation is linked to inflammation and ROS generation [39].