This effect of ORY might again be attributed to the activation of Nrf2 pathways, since Murakami and colleagues [32] demonstrated that Nrf2 activity enhances both proliferation and differentiation of NPCs, and that the functional impairment of Nrf2 retards compensatory neurogenesis in a global brain ischemia model [32]. The gene discussed is NFE2L2; the disease is brain ischemia.