Some liver diseases such as cholestasis and cirrhosis present with hypercholesterolemia, explained by a lower metabolic degradation and excretion of cholesterol along with a deficiency of the enzyme lecithin/cholesterol acyltransferase, leading to the formation of an abnormal lipoprotein called LpX that has little or no apolipoprotein B, which accumulates and leads to hypercholesterolemia [29]. The gene discussed is APOB; the disease is cholestasis.