However, after the WRP, in NG PWO, there was a slight increase in L-SOD activity (non-significant), and in HG PWO, there was a slight decrease in L-SOD activity (non-significant), finally leading to significantly lower levels in the HG group compared to the NG group, thus pointing to the importance of glycemia in obesity as an important factor negatively affecting WRPs. The gene discussed is SOD1; the disease is obesity due to melanocortin 4 receptor deficiency.