Therefore, we set the aim of exploring the relationship of systemic inflammation and the enzymes involved in the GSH metabolism pathway [superoxide dismutase 1 (SOD1), GSH synthetase (GSS), the catalytic and modulatory subunits of glutamyl–cysteine ligase (GCLC and GCLM), GSH peroxidase (GPx), and GSH reductase (GSR)] with smoking data, lung function parameters, the presence of exacerbations, and the Global Initiative for COPD (GOLD) classification categories of COPD. Here, GCLM is linked to chronic obstructive pulmonary disease.