Utilizing myocardial infarction models along with aerobic exercise in fibronectin type III domain-containing protein 5 knockout and Acyl-CoA: cholesterol acyltransferase 1 in knockout mice, the study finds that myocardial infarction significantly reduces irisin levels, contributing to muscle degradation and oxidative stress [151]. This evidence concerns the gene FNDC5 and myocardial infarction.