For example, in experimental models of liver fibrosis, TGF-β1 suppressed the Nrf2-dependent expression of NQO1 (a major antioxidant enzyme) [57,60], and the inhibition of Nrf2 activation by dimethyl fumarate inhibited the profibrotic action of TGF-β1 [58,59]. This evidence concerns the gene NQO1 and Hepatic fibrosis.