TNF and Erythema: Hypericum ointment significantly lowered PASI scores (erythema, scaling, and thickness) compared to the placebo (p = 0.014, p = 0.004, and p = 0.003, respectively). Significant improvement in clinical and histological (spongiosis, acanthosis, parakeratosis, hypogranulosis, thinning of suprapapillary plates, and Munro microabscesses) features of treated lesions in comparison with the placebo was observed (p < 0.05).TNFα concentrations in the dermis, endothelial cells, and dendrite cells were significantly reduced in lesions treated with the drug.