Moreover, we found that enhanced PRKD2 expression in pancreas tissues was connected to reduced DN risk (OR 0.67, 95% CI 0.55–0.81; PSMR 4.05 × 10−5), and the increased expression of SUOX might lower the risk of DR (OR 0.87, 95% CI 0.83–0.92; PSMR 1.10 × 10−7), which were consistent with the results in blood samples. Here, SUOX is linked to liver dysplastic nodule.