A genetically predicted higher level of ICAM1 (OR 1.05, 95% CI 1.03–1.08) was associated with an increased risk of DR, and a higher level of ARG1 was associated with a reduced risk of T2D, with an OR and 95% CI of 0.67 (0.57–0.78). The gene discussed is ICAM1; the disease is type 2 diabetes mellitus.