To investigate the underlying mechanisms, we measured gastric pH as well as the levels of Nuclear factor erythroid 2-related factor 2 (Nrf2), Hemo oxygenase-1 (HO-1), glutathione peroxidase (GPx), and Superoxide dismutase (SOD) in GER-induced rats. This evidence concerns the gene HMOX1 and gastroesophageal reflux disease.