Aberrant cysteine modifications, resulting in proteostasis loss, are found in many proteins involved in ALS pathogenesis, including SOD1, TDP43, peroxiredoxins (PRXs), protein disulfide isomerases (PDIs), AMP kinase, and fibroblast growth factor 2 (FGF2). This evidence concerns the gene FGF2 and amyotrophic lateral sclerosis.