CD86 and neoplasm: The density of CD68+CD163+/CD206+ MΦs dramatically increased from the primary tumor at the early stage to omental metastases at the late stage during EOC progression (early stage to late stage p = 0.0055; early stage to omental metastasis p = 0.0091), whereas the density of CD68+CD86+ MΦs correspondingly decreased (early stage to late stage p < 0.0001; early stage to omental metastasis p < 0.0001), contributing to the shift in MΦs from CD86+ MΦs (M1-like) to CD163+/CD206+ (M2-like) phenotype (Fig. 1A and C; Supplementary Fig. S1A).