AURKA and neoplasm: By adding the clinico-pathologic variables tumor diameter, histologic grade, and lymph node status to the multivariate analysis (METABRIC discovery cohort, all ages, n = 1784), AURKA mRNA demonstrated independent association with shorter disease-specific survival (P < 0.001, HR = 1.44 95% CI 1.26–1.65, Fig. 3E).