Given that the CRISPR screens were performed separately for BRCA1−/− and BRCA2−/− backgrounds, we reanalyzed human cancer genomic data separating BRCA1 and BRCA2 tumors in OV and ER+ BC to identify candidate drivers for each gene individually (Additional file 1: Fig. S11a-b). The gene discussed is BRCA1; the disease is breast cancer.