Therefore, this study strived to perform a GWAS on MetS and its components in a large Korean cohort to identify numerous significant loci that influence metabolic factors, and further investigate the role of SNPs in the APOA5 region, the most significant locus for MetS and two of its diagnostic constituents, plasma triglyceride (TG) and high-density lipoprotein (HDL) levels. This evidence concerns the gene APOA5 and metabolic syndrome.