MC4R and metabolic syndrome: The largest genome-wide association study (GWAS) on MetS has identified lipid-related (ZPR1, CETP, and LPL), obesity-related (FTO, MC4R, and VEGFA), diabetes-related (SLC18A1, ARAP2, and EXOC6), and hypertension-related (SIPA1) genes, and genes with pleiotropic effects simultaneously affecting two or more MetS components (GALNT2, FADS2, NEU2, and CMIP) [7].