APOA5 and metabolic syndrome: GWAS and conditional and joint analysis (COJO) for MetS revealed 11 independent signals: APOA5 on chromosome 11 was the most significant signal (rs651821, odds ratio [OR] = 1.37, P-value = 1.25E-98), which was followed by CETP on chromosome 16 (rs17231506, OR = 0.83, P-value = 2.57E-23), and LPL on chromosome 8 (rs59147390, OR = 0.83, P-value = 1.00E-18) (Fig. 1; Table 2).