POT1 and cancer: POT1 variants reported here, appear to functionally mimic the ssDNA telomere binding defects (Fig. 3G,H), similar to POT1 variants described in familial cancer patients without DC or DCL features (DeBoy et al, 2023; DeBoy et al, 2024; Kelich et al, 2022; Robles-Espinoza et al, 2014; Shi et al, 2014).