ZCCHC8 and Decreased total neutrophil count: Given the RNA dysregulation in ZCCHC8 patients, the recent evolution of PAPD5 inhibitors that can restore functional RNA species in cell models of both DC (Boyraz et al, 2016; Shukla et al, 2020; Fok et al, 2019; Nagpal et al, 2020) and DCL disorder-(Poikiloderma with neutropenia-USB1 deficiency; Jeong et al, 2023) could hold some promise for restoring haematopoietic potential in these patients.