Resident CD34+ cells are the major cells that differentiate into FABP4+ fibroblasts, which exhibit the characteristics of disturbed lipid metabolism; CD34+ cell depletion in ApoE-/- mice alleviated myocardial fibrosis, reduced triglyceride levels, and improved heart function when co-occurring with hypertension and dyslipidemia. Here, CD34 is linked to metabolic syndrome.