To unravel the cellular landscape of noncardiomyocytes in response to hyperlipidemia and hypertension, we obtained 23,321 single cells by integrating three groups from mouse hearts (control, ApoE-/-, ApoE-/-_Ang II) after strict quality control and defined six major cell types, which included fibroblasts (Dcn+, Ddr2+), EC (Cdh5+), neuronal cells (Plp1+), Mac_MO_DC cells (Cd68+), and SMC (Acta2+), based on their respective molecular signatures (Fig. 3b, Supplementary Fig. 5d–g). Here, APOE is linked to hypertensive disorder.