In our study, CD34-CreER;Rosa26-tdTomato&ApoE-/- mice with angiotensin II-induced hypertension were used to observe the unique functions of CD34+ cells in hyperlipidemia and hypertension-induced cardiac remodeling through single-cell RNA sequencing (scRNA-seq) and genetic lineage tracing. This evidence concerns the gene CD34 and hyperlipidemia.