In vitro, the co-culture system of iMSCEndostatin-Her2 (+) tumor cells and iMSCEndostatin-AC16 cells (cardiomyocytes) can simulate iMSCEndostatin (recognition) activated at the tumor site and iMSCEndostatin (non-recognition) unactivated in healthy tissue, respectively. The gene discussed is ERBB2; the disease is neoplasm.