We also performed active mRNA translation sequencing (ART-seq) to capture actively translating transcripts upon IGF2BP3 knockdown (Supplementary Fig. 10a) and validated the protein expression level changes of the representative targets in both HepG2 (Supplementary Fig. 10b and 10c) and other cancer cell lines (Supplementary Fig. 10d and 10e). This evidence concerns the gene IGF2BP3 and cancer.