CD8A and infection: This induced tumor blood VN, enhanced CD8+ T cell and DC infiltration, and non-classical TLS neogenesis.536 Demaria et al. found that using the dinucleotide cGAMP to activate the STING pathway increased the number of CD8+ T cells and inhibited tumor growth, with endothelial cells identified as the main responders to STING activation.537 Additionally, in Influenza A virus-infected IFN-αr1−/− mice, CXCL13 mRNA decreased on the third-day post-infection, but its expression increased after injecting IFN-β in the lungs of wild-type mice.