TNFSF14 and glioblastoma: In a glioblastoma model, it induces HEV formation in the tumor and enhances cytotoxic T cell entry following intravenous injection.239 Researchers have also engineered chimeric antigen receptor (CAR) T cells (Pbbz-LV CAR-T) to express PSMA and LIGHT, and OT-1 T cells (LIGHT-OT-1) to overexpress LIGHT.