ERBB2 and neoplasm: This association positively correlates with early tumor TNM staging, a high quantity of TILs, and the expression levels of Human Epidermal Growth Factor Receptor 2 and Ki-67, while exhibiting a negative correlation with the status of estrogen and progesterone receptors.420 This indicates that a high TLS signature is indicative of a more favorable TEM, leading to better survival outcomes.