This finding emphasizes the significance of tumor microenvironment characteristics in influencing the prognosis of nmCRC patients.384 Furthermore, the presence of mature TLSs is linked to a favorable prognosis in CRC patients, particularly those with nmCRC.404 Additional research highlighted that CRC tissues with high levels of HEVs within TLSs demonstrated enhanced recruitment capabilities for CD3 T cells, CD8 T cells, and macrophages. This evidence concerns the gene CD8A and neoplasm.