In the B16F10-OVA melanoma tumor model injected with LIGHT-OT-1 cells, normalized tumor blood vessels and intra-tumoral lymphatic structures were observed.238 While none of the studies directly detected TLSs, vascular normalization and HEV formation are conducive to TLSs, suggesting that LIGHT is an effective target in regulating TLS formation and anti-tumor effects. Here, TNFSF14 is linked to melanoma.