Moreover, the expression of CXCL13 is closely linked to the presence of TLSs within tumors, further affirming its importance as a marker of TLSs in bladder cancer.256 Analysis also revealed that bladder cancer patients with high levels of TLSs exhibit better prognoses and higher immune cell infiltration compared to those with low TLSs. This evidence concerns the gene CXCL13 and urinary bladder carcinoma.