CR2 and neoplasm: In studies of cutaneous malignant melanoma, it has been found that the presence of TLSs in 47% of cases was associated with an increase in TILs, although the proliferation of lymphocytes within the TLSs did not correlate with TIL proliferation.388 The presence of TLSs was linked to a reduced risk of tumor recurrence and an improvement in OS, particularly in cases with a lower proportion of CD21+ B cells in TLSs.