CXCL12 and neoplasm: The former express multiple cytokines and chemokines, including CXCL12, IL-6, CXCL14, CXCL1, and CXCL2, increasing immune cell infiltration.42 Additionally, Thy1+FAP+ fibroblasts significantly increased in melanoma, and their density in TLSs was higher than tumor parenchyma.43 Notably, fibroblasts from different sites or diseases appear to exhibit different functions in lymphocyte recruitment,10 probably reflecting differences in the activation signals or origination.