Another study confirmed that LTβR agonists increased HEV density in PyMT-BC and RT2-PNET models by 1-fold and 4-fold, respectively, with lymphocyte infiltration.282 Furthermore, anti-LTβR monoclonal antibody agonists can also reverse the disorder of DC subsets in LTβ/LIGHT-deficient mice and promote DC cell proliferation, differentiation, and migration.533 While none of these studies directly detected TLS formation, they provide ideas for future exploration. This evidence concerns the gene LTBR and breast cancer.