The TLSs contribute to the inflammatory burden in nasal polyps by synthesizing immunoglobulins, such as IgE and IgA, as well as proteins such as IL-1β and IL-33, thereby precipitating chronic conditions.302,463–465 More eosinophilic (accounting for 20.69%) and noneosinophilic (accounting for 17.31%) CRSwNP patients have TLSs, with higher levels of IgE, IgG, and IgA in eosinophilic polyps with TLSs, indicating increased inflammation. Here, IGHE is linked to chronic rhinosinusitis with nasal polyps.