BCL6 and neoplasm: Our findings reveal a marked increase in the frequency of CD4+BCL6+ T follicular helper (Tfh) cells within tumor-infiltrating TLS compared to those surrounding the tumor, underscoring the pivotal role of Tfh cells in the maturation and maintenance of germinal centers, thereby shaping the antitumor immune milieu.408,409 High levels of Tfh cells within tumor-associated TLS could be foundational to favorable prognostic outcomes.