Moreover, the expression of CXCL13 is closely linked to the presence of TLSs within tumors, further affirming its importance as a marker of TLSs in bladder cancer.256 Analysis also revealed that bladder cancer patients with high levels of TLSs exhibit better prognoses and higher immune cell infiltration compared to those with low TLSs. The gene discussed is CXCL13; the disease is urinary bladder cancer.