AKT1 and gastric cancer: In TLSs within advanced-stage gastric cancer, B cells produce LTα binding to TNFR2 on the surface of CXCL13+CD103+T cells, which activates tumor necrosis factor receptor-associated factor 2 (TRAF2), enhancing CXCL13 expression through the photoshatidylinositol-3 kinase (PI3K)/protein kinase B (AKT)/mTOR pathway.