Notably, the presence of TLSs bearing mature characteristics, particularly those containing CD23+ GCs, is closely linked to more favorable clinical outcomes in ccRCC patients.412 Analyses of TME in ccRCC and adjacent non-cancerous tissues have demonstrated significantly higher levels of CD8 T cells, CD163+ macrophages, regulatory T cells, endothelial cells, and fibroblasts in ccRCC tissues. This evidence concerns the gene FCER2 and nonpapillary renal cell carcinoma.