IL-17 plays a key role in the formation of TLSs.218 Th17 cells secrete IL-17, which promotes FRC proliferation, maintains the FRC network, and induces the secretion of CXCL13 and CCL19.219 In IgG nephropathy, blocking IL-17A significantly impaired TLS formation, which decreased kidney damage.219 It can also be observed that IL-17 promotes TLS formation in the inducible bronchus-associated lymphoid tissue (iBALT).220 However, Fleige H. and colleagues found that IL-17 is not a determinant of iBALT development. This evidence concerns the gene IL17A and Nephropathy.