IFNG and neoplasm: A study suggested that the pH of the T-cell area in the LN (6.3) was significantly lower than other sites (LN peripheral pH 7.1 and peripheral vessel pH 7.1).433 Due to aerobic glycolysis occurring in T cell activity leading to lactate accumulation.434 However, decreased pH inhibits T-cell lactic acid efflux and glycolysis, and suppresses cytokine release, such as IL-2 and IFN-γ, but not T-cell activation.433 Tumor cells are characterized by aerobic glycolysis, which suppresses T cell function.