The B cell activation marker CD83 and BAFF co-enriched in the B-cell zone of TLSs in encephalomyelitis.244 It suggests that elevated levels of BAFF contribute to B cell activation and PC differentiation.245 Conversely, blocking BAFF leads to a decrease in newly formed TLSs, reducing infiltration of B cells and T cells, preventing TLS formation, and mitigating lupus nephritis.246–249. This evidence concerns the gene TNFSF13B and encephalomyelitis.