In NSCLC, NCR+ ILC3 increases in proximity to TLSs, producing IL-22 in response to IL-23 stimulation.186 Another study reported that IL-21 increases IL-22 and Tbet production by ILC3 while decreasing IL-17 expression, thereby exerting a protective role in intestinal inflammation.187 Altogether, the available evidence suggests that ILC3 acts as LTi cells involved in TLS formation, which can be activated by diverse stimuli to produce multiple effectors. This evidence concerns the gene IL22 and non-small cell lung carcinoma.