Radiotherapy triggers NK cell migration to the irradiated tumor by NF-κB and mTOR-coordinated irradiated tumor cells to secrete chemokines.489 In addition, local radiation therapy induces increased expression of MHC-II molecules as well as death receptors FAS/CD95 and DR5 on tumor cell surfaces, and synergies with antigen vaccines.490 A study examined tissue samples from 198 patients who had undergone surgery and found that TLSs are associated with a favorable prognosis for lung adenocarcinoma (LUAD). This evidence concerns the gene NFKB1 and neoplasm.