Notably, IL-17 inhibitors can reverse the abnormal activation of TLSs caused by the lack of the IL-27 signal.207 Liu et al. found that delivering IL-12 and IL-27 mRNA promoted immune effector cell infiltration, mainly CD8+ T cells and NK cells, and significantly inhibited tumor growth.538 This result is the synergy of IL-12 and IL-27 and does not appear to conflict with the role of IL-27 in inhibiting the GC response in TLSs. This evidence concerns the gene CD8A and neoplasm.