For example, CXCL13 and CCL21 recruit lymphocytes by binding to CXCR5 and CCR7 respectively, which is related to TLS formation.524 In a mouse ovarian cancer model, intraperitoneal injection of recombinant CXCL13 increased intra-tumor TLSs. This evidence concerns the gene CXCR5 and neoplasm.