IL10 and breast cancer: They secrete prostaglandin E2 (PGE2), reactive oxygen species (ROS), and IL-10 and also contribute to the secretion of antibodies and IL-6 by activated B cells.164 In breast cancer, CD169, or TLS, is associated with decreased odds of surviving for 5 years.165 Furthermore, TIM4 expression in FOLR2+ resident macrophages was positively related to prognosis.