These studies reveal that the coexistence of CD8 T cells and B cells in the tumor microenvironment (TME) significantly improves the prognosis of HGSOC, which is associated with the presence of TLSs.254 The expression of CXCL13 transitions to CD21+ follicular DCs as TLS matures, initially emanating from CD4 T cells. This evidence concerns the gene CD4 and neoplasm.