CD40LG and Sjogren syndrome: A recent study on TLSs in OSCC showed that high-grade TLSs coincided with the infiltration of CD57+ NK cells.173 Furthermore, NKp30+ NK cells increased in Sjogren syndrome with TLSs, activating B cells to produce antibodies (IgG, IgM, and IgA).182 Circulating NK cells were recruited to salivary glands before TLS appearance, upregulating NKp46 expression and producing granzyme B and IFN-γ.183 Additionally, NK cells act as LTi cells and express IL-22 to induce chemokine production (CXCL12, CXCL13) in stromal cells.184