The results showed a strong and significant decrease of IL-10 in all B-CLL cells co-cultured with BAG3-silenced HS-5 (IL-10 mean ± S.D.: 10.5 ± 1.3) when compared to controls (IL-10 mean ± S.D.: 21.9 ± 1.8), thus proving, or letting infer, a sound correlation between BAG3 expression in stromal fibroblasts and IL-10 levels in the TME (Fig. 4C). The gene discussed is BAG3; the disease is B-cell chronic lymphocytic leukemia.