CTSH and plasma cell myeloma: Furthermore, when comparing the transcriptomic profiles of TC-RK induced myeloma with human myeloma cases, there was a notable correspondence, particularly in the upregulation of myeloma-associated genes such as Birc5, Ezh2, Prc1, and Foxm1 (p = 1.2 × 10−5; OR = 1.7), and in the downregulation of genes like Cd19, Ctsh, and Tmsb4x (p = 1.7 × 10−4; OR = 1.6; Supplementary Table 1) [34, 35].