To clarify the effect of lncRNA HAGLROS on angiogenesis in breast cancer cells, endothelial tube formation and VM results showed that lncRNA HAGLROS overexpression significantly promoted neovascularization and luminal structure formation ability in HUVECs, HLECs and breast cancer cells, and vice versa (Fig. 3E–G). This evidence concerns the gene HAGLROS and breast cancer.