This study elucidated that lncRNA HAGLROS/miR-135b-3p/COL10A1 signaling axis is closely related to breast cancer development, and that exosomes play an important role in breast cancer TME by transferring lncRNA HAGLROS, which is expected to be a novel molecular marker for breast cancer diagnosis and prognosis, and provides a new target for targeted therapy of breast cancer. Here, COL10A1 is linked to breast carcinoma.