FN1 and neoplasm: In pre-treatment scans of mice, mice slated to enter the miR-200c group showed strong bright signal enhancement throughout the tumors, indicating elevated expression of EDB-FN, over mice assigned to the saline group Fig. 3C. Substantial signal reduction was observed in the miR-200c treated tumors on day 26 and 46 compared to the pre-treated tumors, indicating a reduction of tumor EDB-FN expression with miR-200c treatment, Fig. 3C. The MRMI signal remained unchanged in the siNS treated tumors over the course of dosing and monitoring, similar to the saline control, Fig. 3C.