Aside from the severe hemolytic disorders secondary to inherited conditions (hemoglobinopathies, glucose-6-phosphate dehydrogenase) or pyruvate kinase deficiencies), immune-mediated anemia, or anemias due to the physical damage of RBC (by artificial heart valve or during hemodialysis), many other factors are reported to be associated with a high risk of intravascular hemolysis (33). The gene discussed is G6PD; the disease is hemoglobinopathy.