There are three mechanisms associated with the regulation of the expression of the miR-200 family: 1) suppressing epithelial–mesenchymal transition (EMT) and tumor metastasis via the miR-200/ZEB1-2 axis [5], 2) reversing chemoresistance [6], and 3) inhibiting cancer stem cell self-renewal and differentiation [7]. The gene discussed is ZEB1; the disease is neoplasm.