By further investigating the CT frequency of this CN, we found that the original tumor boundary CN is highly mixed, whose entropy is 3.31 and top 5 major cell types are tumor cells (39.36%), CD68+CD163+ macrophages (9.78%), granulocytes (7.70%), stroma (6.66%), and tumor cells / immune cells (4.45%). This evidence concerns the gene CD68 and neoplasm.