Several mechanisms have been proposed behind chemotherapy-induced cachexia, including the generation of reactive oxygen species (Gilliam and St Clair, 2011), activation of proteases like calpain and caspases (Gilliam et al., 2012; Smuder et al., 2011), and impaired insulin signaling (de Lima Junior et al., 2016). This evidence concerns the gene INS and Cachexia.