As mentioned, MC38 tumors are highly immune infiltrated, and additional effects such as the efficient capture of the radiolabeled antibody by tumor associated macrophages via Fcg receptors and its subsequent retention in this cell population is also a possible mechanism contributing to the high CXCR3 independent tumor uptake of [64Cu]Cu-NOTA-α-CXCR3 [33]. This evidence concerns the gene CXCR3 and neoplasm.