CRTAC1 and pulmonary arterial hypertension: In addition, the roles of NID1 (ref. 46), C1QTNF1 (refs. 42,47), SPARCL1 (ref. 48), CRTAC1 (ref. 45) and MEGF9 (ref. 49) in cardiac remodeling confirmed their relevance to and the prognostic significance for RV dysfunction in PAH.