Based on the calculated feature importance score (Methods), CRTAC1 and NID1 were highly predictive in the discovery cohort (Fig. 7d), while in the validation cohort, NID1 and C1QTNF1 had the most predictive performance in discriminating compensated and decompensated states of the RV samples of PAH participants (Fig. 7e). This evidence concerns the gene C1QTNF1 and pulmonary arterial hypertension.