SPP1 and pulmonary arterial hypertension: We confirmed the remaining ECM molecules (ITGA10, ITGB6, HMMR, MMP9, SPP1 and TIMP1) with no proteomics record in public datasets, as either regulated in plasma of PAH participants (MMP9 and TIMP1)12,14, or similarly regulated in transcriptomes from other rat models of PH5,6.