Several known mechanisms implicated in atherosclerosis and ischemia were represented among the other 94 biomarkers associated with an IMI in both the discovery and validation samples after adjusting for technical covariates, including inflammation (IL-6)14, extracellular matrix metabolism (WAP four-disulfide core domain protein 2 (WFDC2))15, hypertrophy (adhesion G-protein-coupled receptor G1 (AGRG1))16, apoptosis (triggering receptor expressed on myeloid cells 1 (TREM1), tumor necrosis factor receptor superfamily member 10B (TRAIL-R2)) and cell adhesion (AGRG1). Here, TREM1 is linked to ischemia.