After MI, Creld2-deficient mice developed bigger infarct scars than the wild-type controls (Fig. 4a), with more pronounced LV dilatation and systolic dysfunction, as shown by microcatheterization (Fig. 4b and Supplementary Table 3) and serial echocardiography (Fig. 4c,d). The gene discussed is CRELD2; the disease is myocardial infarction.