Most recently, by evaluating the prognostic value of IGFBP7 in a large cohort of new-onset or worsening HF (BIOSTAT_CHF cohort), it was found that IGFBP7 pathways are involved in different stages of immune system regulation, linking HF to senescence58, which serves as a direct validation of our finding in a larger HF cohort. This evidence concerns the gene IGFBP7 and congestive heart failure.