Four weeks after TAC and injection, Igfbp7 knockdown attenuated TAC-induced heart weight/body weight (HW/BW) and lung weight/body weight (LW/BW) increase in AAV9-mCherry-U6-mIgfbp7-shRNA-injected mice (Fig. 7c). The gene discussed is IGFBP7; the disease is persistent truncus arteriosus.