Therefore, as summarized in Fig. 5j, IGFBP7 promotes cardiac senescence by stimulating IGF-1R/IR/IRS/AKT-dependent suppression of FOXO3a, preventing DNA repair and ROS detoxification, suggesting that inhibition of IGFBP7 could be therapeutically beneficial for senescence-related HF. Here, IGFBP7 is linked to hydrops fetalis.