Here we show that expression of IGFBP7 in cardiomyocytes is robustly increased in patients with HF and in murine pressure overload HF and mediates elevated plasma IGFBP7 and other SASP proteins as well as elevated senescence markers CDKN2A (p16), CDKN1A (p21) and TP53 (p53) in peripheral blood. The gene discussed is TP53; the disease is hydrops fetalis.