Increased heart weight normalized with tibia length (HW/TL) (Fig. 3a), a key indicator of left ventricular hypertrophy, and increased lung weight (Fig. 3b), a sign of congestive HF, were observed in WT mice but not in Igfbp7−/− mice after TAC surgery (Extended Data Fig. 3a). Here, IGFBP7 is linked to left ventricular hypertrophy.