Recently, through integrative analyses of scRNA-seq and spatial transcriptomics, in a study focused on cardiac fibroblasts in regulating the development of HF, it was found that IGFBP7 is secreted from failing cardiomyocytes57, which validated our finding that IGFBP7 is robustly upregulated in cardiomyocytes upon stress. This evidence concerns the gene IGFBP7 and hydrops fetalis.