PKP2 and arrhythmogenic right ventricular cardiomyopathy: Previous studies identified a PKP2 RNA splice acceptor site mutation (PKP2 IVS10-1G>C) in multiple ARVC populations in which patients displayed classic ARVC disease features11,15,21,22, contributing to the idea that alterations in PKP2 RNA splicing may be a critical mechanism through which PKP2 patient genetics drive ARVC.