More direct evidence of RNA involvement is suggested by studies that show that altered RNA splicing may also be a critical mechanism through which PKP2 patient genetics drive ARVC11,15, highlighting that altered PKP2 RNA levels may be a critical trigger of ARVC pathogenesis in patients with ARVC who have PKP2 mutations. This evidence concerns the gene PKP2 and arrhythmogenic right ventricular cardiomyopathy.