PKP2 Hom mice were injected with AAV at 5 × 1011 genome copies per mouse on postnatal day 2 and subsequently analyzed at 4 weeks of age (Fig. 5b), a time point at which all ARVC disease features are present (Figs. 1 and 2). This evidence concerns the gene PKP2 and Arrhythmogenic right ventricular dysplasia.