Four weeks of mAb2 treatment under lipid-lowering conditions reduced atherosclerosis in en face aorta (Fig. 4c,d) and the BCA (Fig. 4e,f), and apoB content, macrophage infiltration, plaque necrosis, collagen content and fibrous cap thickness in the BCA (Extended Data Fig. 10d–m). This evidence concerns the gene APOB and atherosclerosis.