A hypertrophic cardiomyopathy phenotype is unrecognized for Leprotl1. By contrast, mice with homozygous loss of Ints6l (integrator complex subunit 6 like) or Abhd3 (abhydrolase domain-containing 3) had an increase in LV diameters (LVIDs and LVIDd) with decreased systolic function, indicated by reduced fractional shortening and ejection fraction. This evidence concerns the gene INTS6L and hypertrophic cardiomyopathy.