LEPROTL1 and hypertrophic cardiomyopathy: A hypertrophic cardiomyopathy phenotype is unrecognized for Leprotl1. By contrast, mice with homozygous loss of Ints6l (integrator complex subunit 6 like) or Abhd3 (abhydrolase domain-containing 3) had an increase in LV diameters (LVIDs and LVIDd) with decreased systolic function, indicated by reduced fractional shortening and ejection fraction.