DSG2 and heart disorder: This analysis indicated that 178 of the 664 mouse–human orthologous genes (41 nonorthologous genes) were previously linked to heart disease, some of which functionally converge on skeletal and cardiac muscle structural integrity (for example, LDB3)36, cardiac development (BMP10)37, calcium signaling (CACNB2 and DSG2)38,39, sodium channels (SCN2B)40 and sarcomere contraction cycle (TNNC1 and MYH2)30,41.