In addition, the increased abundance of apoptotic proteins (Aifm1 and Casp3) and the deficiency of cell function proteins (Pla2g7, Spta1, Sptb, Ipo5, Bsg, Gp1ba and Ptk2b) in neutrophils from stroke mice indicated the activation of cell death pathways that have been observed in association with chromatinolysis20 and NETosis21. The gene discussed is CASP3; the disease is Stroke.