A recent study using echocardiography for a porcine MI model showed that the end-diastolic mean wall stress of the BZ is increased from acute phase of MI and that myocardial stiffness of this region also reaches the plateau by 14 days after MI30, suggesting that cardiomyocytes activate the expression of Csrp3 in response to mechanical stresses caused by MI. This evidence concerns the gene CSRP3 and myocardial infarction.